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Immunohistochemistry of brain tissues from mice treated with GHK showed evidence of decreased inflammation and increased labeling of histone deacetylase 2, suggesting that in addition to an anti-inflammatory effect, GHK may be triggering an epigenetic pathway in the amelioration of cognitive impairment in aging mice

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Both peptides stimulate endogenous GH release, but their approved applications and clinical trial data reflect different therapeutic windows and patient populations

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BioChemistry 25:35083515 Tomita T, Kuzuyama T, Nishiyama M (2011) Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase