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Physical dependence : Long-term use leads the body to rely on the substance to maintain baseline functioning, so abrupt cessation forces the body into a shock state, manifesting as withdrawal

With new approvals and expanding access, nephrology and primary care clinicians are increasingly incorporating GLP-1 medications into long-term CKD prevention strategies

That could cause you to lose too much weight

The primary issue with the Paragard IUD device revolves around its tendency to break upon removal, potentially causing severe pain, injury, and additional surgical interventions to retrieve broken pieces

For the full evidence base, see DSIP Benefits