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Conversely, the most recent systematic review and network meta-analysis from 2025 by Oliva et al [23], including 13 RCTs and 1,362 patients with bipolar depression, concluded that: although some evidence of increased risk of switching to mania was observed, no antidepressant was associated with a significantly higher risk of switch to mania compared to placebo

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Het is in grote hoeveelheden aanwezig in de spieren en is een sleutelcomponent bij het transport van vetzuren naar de mitochondrin, waar ze worden gebruikt in metabolische processen die energie produceren