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This analysis was a prespecified secondary analysis of the SUMMIT Trial, which showed that the long-acting glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist tirzepatide decreased risk of cardiovascular death or worsening heart failure (HF) in patients with (HFpEF). As it pertains to sex, the investigators noted that women outnumber men with HFpEF, and there are sexual dimorphisms in the relationships between body fat and pathophysiology in HFpEF that could influence response to tirzepatide. In the SUMMIT trial, the investigators analyzed 731 patients (338 men, 393 women) with class II-IV HFpEF and BMI of 30 kg/m 2 or greater
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(Revised 7/24/2017) A: The Independent Assessor conducted the Mid-Point Assessment using data sources that were available at the time of the assessment and worked to minimize the amount of additional reporting required by the PPS
Expert Insight / Pro Tip When analyzing multi-peptide blends, always account for the total aggregate mass versus the individual peptide concentrations