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It is commonly associated with PRKAR1A mutations and Carney complex, a genetic disorder characterized by multiple neoplasia

doi: 10.1900/RDS.2011.8.293

In clinical settings, the origin of CSCs remains debated: it is unclear whether CSCs arise from NSCs that acquire oncogenic mutations or from differentiated cancer cells that dedifferentiate under selective pressure, such as hypoxia, inflammation, or therapeutic insult