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doi: 10.1111/pcmr.12365

The method of claim 1 , wherein the PDE-5 inhibitor is administered between about 5 and 45 minutes prior to administration of PT-141

27 Decreased expression of xCT leads to an increase in the rate of sulphur transfer from homocysteine to cysteine (through the trans-sulphuration branch of the methionine cycle), supporting the pivotal role of xCT in cyst(e)ine transport and cysteine provision