doi: 10.1152/ajprenal.00012.2017 18 LiangNYuanXZhangLShenXZhongSLiLet al
While not studied extensively, there appears to be a series of internal skin factors that are turned off by the GLP-1 drug that cause skin to look duller than usual, more wrinkled, and have more sun-induced pigmentation
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Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)