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The clinical evidence for berberine is more robust than many people realise: A landmark 2008 study published in Metabolism found that berberine was as effective as metformin in reducing fasting blood glucose, HbA1c, and post-meal blood sugar in patients with type 2 diabetes

Additionally, the Spatial Error Model (SEM) confirms the moderate spatial autocorrelation of the data, validating the robustness of the findings

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The metabolic improvements and weight loss achieved with incretin-based therapies are associated with improved fertility

doi: 10.1056/nejmoa2307563