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Suresh MV, Balijepalli S, Solanki S et al (2023) Hypoxia-inducible factor 1 and its role in lung injury: adaptive or maladaptive

Cell culture, plasmid transfection, and co-immunoprecipitation (co-IP) Mouse fibrosarcoma cells (MCA205) were obtained from the National Cancer Institute and sold by Shanghai Yu Bo Biotech (Shanghai, China

It's one of the most important hydrophilic antioxidants in the human body that protects cells against exogenous and endogenous toxins, including reactive oxygen (ROS or free radicals) and nitrogen (RNS) species 1

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We hypothesized that the observed lower GSH:GSSG ratio in asthmatic lung fluids and cells is at least partially driven by high oxidation of GSH and its export in response to greater intracellular 15LO1/PEBP1 pathway activity