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doi:10.1002/9780470123188.ch9

TXNRD1 has emerged as a selective vulnerability in KRAS -wild-type and KRAS inhibitor-resistant tumors, where its blockade induces ferroptosis through combined GSH depletion and iron overload 117

Patients carrying certain genetic variants may require higher doses to achieve the same appetite suppression as those with favorable genotypesyet many never discover this mismatch