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NNMT inhibition increases NAD+ levels and enhances sirtuin-mediated mitochondrial function

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Preclinical models of TNBC and HER2+ breast cancer have shown that this immune response can suppresses the development and spread of the malignancy (91)

We noticed that LPS stimulation resulted in Ser184 phosphorylation and greatly raised the phosphorylated Ser42 and Tyr198 level (Figure 5A), but phosphorylation of Tyr3 and Tyr7 was not altered by LPS challenge

To assess statistical differences between groups, univariate comparisons were conducted using two-sample t-tests with confirmation by Wilcoxon rank-sum tests, given the small sample size