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There are numerous reasons for an altered microglial secretory profile in aging, but one specific to white matter regions could be an increase in myelin debris that cannot be efficiently cleared/metabolized by microglia, resulting in cellular stress (Safaiyan et al., 2016)

Host and microbial regulation of mitochondrial reactive oxygen species during mycobacterial infections

This resulted in the restoration of proliferative capacity and escape from senescence [51]

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Lee FJ, Liu F, Pristupa ZB, Niznik HB