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Exenatide targets the GLP-1 receptors located at the choroid plexus epithelium, the structure responsible for the majority of CSF secretion in the brain [16, 17]

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In fact, it is not only tumor microenvironments which can educate immune cells since for instance, the GM-CSF can license murine and human monocytes toward their immunosuppressive phenotypes through the PI3K/AKT/mTOR signaling pathway [90]