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Endotext (2024) Once-weekly semaglutide in adults with overweight or obesity, New England Journal of Medicine (2021) Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension, Diabetes, Obesity and Metabolism (2022) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

doi:10.1097/00001622-200103000-00008

Interestingly, the neural circuits responsible for the metabolic effects of GLP-1R agonism may be distinct from those mediating nausea or malaise (Huang et al., 2024), suggesting that future therapies could be tailored to preserve metabolic benefits while minimizing gastrointestinal side effects

This makes Ozempic and Wegovy convenient for long-term treatment

It is possible that ongoing oxidative stress in the brain related to PTSD is depleting GSH concentrations and the lower TIMP-2 is detected in peripheral circulation due to enhanced BBB permeability