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Itoh, K., et al., An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

These results are notable in that Veterans of the 1990-1991 Gulf War who received vaccines containing aluminum hydroxide adjuvant demonstrate a significant increase in the incidence of ALS, implicating aluminum toxicity as one potential environmental factor in some forms of sporadic ALS [62, 63]

The peptide has an arginine in place of glutamic acid at position 3, and an extra 13-amino-acid extension on the front (the N-terminus ), making the full chain 83 amino acids instead of native IGF-1's 70