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DOI: 10.1126/science.3659910

Romiplostim and eltrombopag for immune thrombocytopenia: methods for indirect comparison

Common mistakes include not accounting for the purity of the powder, using an imprecise scale, or improperly reconstituting the compound

Its weight-reducing effects are particularly notable, offering a promising option for patients with concomitant obesity, a common comorbidity in T2D

In this review, examples will be discussed how experimental conditions (dose, solvent, etc.), the experimental system (species, strain, and substrain in vivo, cell type, and in vitro conditions), and also adaptive responses and off-target effects of genetic manipulations and chemical interventions, can impact the mechanisms of cell death