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As oligodendrocytes are the main sites of iron storage in the brain 24 , the stimulation of FPN1-mediated iron export via decreased hepcidin is expected to increase free extracellular iron, which may, in turn, result in oxidative stress in the SN in PD patients

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Comment: Several commenters recommended refining the HCHE and FCHE measures rather than removing them entirely

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In vivo studies revealed successful delivery of the model drug into the human adipose tissue followed by ~15% decrease of weight gain after a four-week treatment