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Results Combined administration of native amylin and GLP-1 or their receptor analogs enhanced the suppression of food intake and body weight gain compared to individual monotherapies To provide a detailed analysis of the behavioral mechanisms mediating the food intake suppressive effects of native amylin and GLP-1 when acutely administered alone or in combination, rats ( n = 14) were placed in our automated feedometer system with ad libitum access to chow and water and meal patterns were objectively analyzed