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Relative Contraindications: Injection into Fingers & Toes Historically, the injection of epinephrine containing solutions into end-artery structures such as fingers and toes has been widely discouraged due to the concern that prolonged vasoconstriction may cause vascular insufficiency resulting in tissue necrosis and permanent injury

At therapeutic doses, approximately 90% of the drug undergoes conjugation with glucuronide and sulphate, producing harmless metabolites that are excreted in urine