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Peroxisome proliferator-activated receptor alpha (PPAR) and its co-activator, peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1), function as upstream regulators of mitochondrial biogenesis and functionality

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The soft callus is visible on X-rays as a cloudy mass surrounding the fracture line, and its size often correlates with eventual healing success

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