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It is advised to begin from the lowest dose (0.25 mg) and slowly increase it every four weeks or every eight if the increased dosage is not well tolerated and causes symptoms originating from the gastrointestinal tract

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The process involved diastereoselective oxidation of a cationic ruthenium complex, providing an efficient route to the desired enantiomer [135], Figure 19

Signs of an allergic reaction: These include hives, swelling of the face or throat, or difficulty breathing