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Tirzepatide added a second receptor, GIP, and its trials reported roughly 2122% average weight loss over 72 weeks, making it more effective than semaglutide in head-to-head comparisons

Step 2: Prepare the pen For pens with separate needles (such as the Mounjaro KwikPen): attach a new needle, remove the outer and inner needle caps, and prime the pen according to the IFU by turning the dose knob and pressing the injection button until a droplet appears at the needle tip

Those taking the medication experienced nearly 50% less volume loss in critical brain regions responsible for memory and decision-making 30

Some patients start noticing weight loss within the first few weeks, while others may take longer

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