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A few mechanisms that don't reduce neatly to mesolimbic dopamine: (1) conditioned aversion, GLP-1 activation engages nausea/malaise circuits, so some of the reduction in substance use may reflect aversive conditioning rather than reward modulation per se

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Lower glutathione levels are implicated in many diseases associated with aging, including cataracts, Alzheimers disease, Parkinsons, arteriosclerosis and others

doi: 10.1007/s12263-011-0243-9 120 FerreiraRLUSena-EvangelistaKCMde AzevedoEPPinheiroFICobucciRNPedrosaLFC