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Cardiovascular effects Heart rate increased in a dose-dependent manner during the first 24 weeks of treatment, with the largest average increase being approximately 6.7 beats per minute at the 12 mg dose

Taking these observations together, we hypothesize that endogenous oxidation by dysregulated melanin biosynthesis is responsible for the melanomas in unirradiated animals and contributes to the increased melanoma multiplicity in all pigmented groups

Rhonda: Uh, you know, so physical activity was a stressor, you know, that is that is stressful on the body

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10.1089/dna.2018.4397 17 GaoQ.WangL.WangS.HuangB.JingY.SuJ