It was demonstrated that in the spinal cord of the SOD1-G93A ALS mouse model, the mitochondrial receptor SQSTM1/p62 is recruited to the mitochondrial surface, where it activates mitophagy, whereas knockdown of the Parkin gene reduces the loss of motor neurons, thereby delaying the progression of disease in SOD1-G93A mice (Palomo et al., 2018)
Results in panels F to I are mean SEM ( n = 4 in each genotype) determined by 2-way ANOVA and Sidaks multiple comparison posthoc tests
Thus, data in support of each hypothesis was derived from different animal models, with mitochondrial oxidative stress being critical for APAP hepatotoxicity in mice on a normal diet, without appreciable LPO generation
Available from: ACLS Algorithms.com (2026): Cited 3/23/2026
PPIs also cause the reduction of other bacteria that produce BSH, such as Bifidobacterium