Based on these data, together with the earlier studies on the specificity of monomeric macrocycle binding to Met, we conclude that the observed downstream phosphorylation events are triggered by the specific activation of Met by the dimeric macrocycles
To evaluate the observed response, we measured cAMP from sinus node superfusates collected right before and 15 min after GLP-1 exposure, as well as in supernatants from sinus nodes statically incubated with or without GLP-1 for 30 min
GLP-1 agonists are medications designed to replicate the effects of a natural hormone in the body called glucagon-like peptide-1
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