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While the prescribing information for GLP-1 medications does not specifically list Crohn's disease as a contraindication, the Summary of Product Characteristics (SmPC) for these medicines does advise caution in patients with gastrointestinal disease and states they are not recommended in severe gastrointestinal disease

& Haavik, J

Ozempic (semaglutide) is a GLP-1 receptor agonist, which is a completely different class of medication

Guidance for Industry: Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products-Chemistry, Manufacturing, and Controls Documentation [Internet] (accessed November 30, 2025) [Google Scholar] Ugwoke M., Agu R., Verbeke N., Kinget R

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