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In conclusion, the available evidences regarding the effect of homocysteine lowering therapies on CKD progression are controversial and further studies with CKD progression as primary end-point and more homogeneous population selection are needed

Swim latency, swim distance, time spent in the target quadrant, and number of quadrant crossings were recorded using a computerized video tracking system [2]

However, all observed effects derive from animal models and in vitro research systems