Among these diseases, the potential common denominators in the pathologic mechanisms are processes such as cell proliferation and differentiation, inflammation, and fibrosis, and the role of Wnt/-catenin signalling in these processes is well established, explaining why the Wnt/-catenin signalling pathway plays a key regulatory role in these diseases
It has one genuine pharmacological advantage (reduced IGFBP binding extending free-peptide availability) that is real at the molecular level but unproven to translate into superior clinical outcomes in humans
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Randomization was well-executed, reinforcing the trials methodological rigor
