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A key part of the process involves macrophages, immune cells that help to repair tissue after injury but can also drive excessive scar formation when immune responses fail to resolve properly

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In a phase 3 clinical trial, orforglipron lowered patients body weight by an average of 12.4 percent (or 27.3 pounds) compared to 0.9 percent (2.2 pounds) in those who took a placebo

It supports healthy GLP-1 activity to balance hunger, metabolism, and energy

Controlled human trials are needed to confirm efficacy