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Extracellular matrix regulation in connective-tissue models. J Invest Dermatol

This could be associated with the damage to cell component, basement membrane and epithelia by lipid peroxidation, protein denaturation and enzyme inactivation in vascular endothelial cells

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however, when handled as a research chemical: Effects are dependent on concentration, exposure conditions, and experimental model High concentrations in vitro may alter cellular redox balance and produce unintended experimental outcomes Long-term effects in experimental systems depend on study design and conditions Handling Precautions: Use appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection Avoid inhalation, ingestion, or direct contact with skin and eyes Handle under controlled laboratory conditions using standard safety protocols Regulatory Status: Not approved by the U.S