Critically, these decidualization and matrix remodeling defects do not occur in isolation: they frequently co-occur with immune dysregulation, suggesting that RIF may represent a syndrome of coordinated endometrial dysfunction rather than a single-pathway failure [287, 297]
At the cellular level, glutathione is a fragile tripeptide
Vitamin E is a fat soluble vitamin, and in theory, it can build up in the body
Moreover, further endothelial maintenance, mediated by continued VEGF signaling, and additional growth factor interactions (insulin-like growth factor-1 (IGF-1) and platelet-derived growth factor (PDGF)) all promote vascular remodelling and luteal maintenance ( When there is no pregnancy, the CL experiences functional and structural regression which is closely linked with vascular destabilization
Chondrocyte matrix synthesis Proteoglycan production: Chondrocytes synthesize aggrecan (large proteoglycan) providing cartilage's compressive resistance