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The most important rule is to start low and go slow

& Minami, K

273 Moreover, GLP-1RAs could decelerate the progression of OA and mitigate pathological damage in a rat OA model

In the brain, the highest densities of GLP-1R are found in the nucleus of the solitary tract, posterior area, interpeduncular nucleus, posterior dorsal nucleus, ventral tegmental area, hypothalamic nuclei, thalamic nuclei, nucleus accumbens, and the lateral septum [5]