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Dahnhardt et al, in 2024, conducted a pilot study in Germany investigating the effects of a 12-week administration of a custom nutraceutical supplement (given daily) that contained special collagen peptides on the structural properties of the collagen fiber network in human skin [47]

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Chemistry & Biodiversity, 7 (6), 1459-1466

Your stomach acid completely breaks them down before they ever reach your bloodstream

The primary limitation is bioavailability: oral glutathione supplements are largely ineffective due to breakdown in the GI tract, and even liposomal formulations show inconsistent absorption