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Longer exposure, combined with full-dose maintenance after titration, produces substantially deeper weight loss

For insulin syringes, this is approximately 0.5 to 1 unit

In the book, Kessler acknowledges that you can't really separate those unpleasant feelings from the effective mechanism of the drugs themselves

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This includes a rare but serious condition called non-arteritic anterior ischaemic optic neuropathy (NAION), also known as an "eye stroke." A related research suggested that the chance of getting NAION from semaglutide was about 1 in 10,000