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Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)

Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent study

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Moreover, some people eat less when they are depressed, which can lead to inadvertent weight loss