Proceedings of the National Academy of Sciences , 84(10), 34343438
Next-generation agents, including triple agonists such as retatrutide, extend beyond GLP-1 and GIP to include glucagon receptor activation, introducing a new dimension of energy expenditure and metabolic regulation
Standard error of the mean SNc Substantia nigra pars compacta SLE Systemic lupus erythematosus STZ Streptozotocin SORT Selective organ targeting SSTR2 Somatostatin receptor 2 T2DM Type 2 diabetes mellitus T1DM Type 1 diabetes mellitus TEM Transmission electron microscopy TH Tyrosine hydroxylase TNBS Trinitrobenzene sulfonic acid UUO Unilateral ureteral obstruction UCP1 Uncoupling protein 1 USPIO Ultrasmall superparamagnetic iron oxide UTMD Ultrasound-targeted microbubble destruction WAT White adipose tissue WD Western diet ZnO NPs Zinc oxide nanoparticles ZDF rats Zucker diabetic fatty rats Author contributions Juan Zeng: Writing original draft
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A new study, Ophthalmic Complications Associated With the Antidiabetic Drugs Semaglutide and Tirzepatide , has raised concerns that these widely used medications may be linked to an increased risk of certain vision-threatening conditions