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We review studies revealing the neuroprotective actions of GLP-1 analogues in pre-clinical models of AD and PD and promising results from recent clinical trials

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

The pooled outcomes for tirzepatide showed a more significant positive impact in each individual lipid measure as compared to semaglutide in a population with similar baseline characteristics

However, despite increased use both on- and off-label, widespread media attention and a need for new tools in the fight against obesity, the real-world effectiveness and safety of these medications outside of clinical trials are still under investigation

FDA (2025)