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Current second-generation CB1 inhibitors, small molecules potentially more peripherally restricted than rimonabant, still exhibit brain accumulation6 in preclinical models, indicating a possible persistent safety issue

Albumin uptake by astrocytes is mediated by transforming growth factor, and is followed by downregulation of inwardly rectifying potassium channels, impacting buffering capacity (73)

To enhance delivery efficiency, viral fusogenic proteins have been introduced into EVs in the s-EV fractions 13,15,16 , but this diminishes their advantage as a virus-free alternative

That decision is yours to make with your prescribing physician, and it should be made with full understanding of what the evidence actually supports versus what biological plausibility suggests might work