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At high concentrations, comparable or higher than the dissociation constant of the ubiquitous 1-isoform of Na,K-ATPase, CTSs exert an inhibitory effect on ion transporter, resulting in a cytotoxic effect at long-term exposure

The current drug for diabetic patients with a fracture requires repetitive injections and hospital visits and as a result patient compliance is low

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The general mechanism of the mutual balance between the metabolic pathways of fungi still needs further research, but the inhibition of fungal metabolism from the perspective of multi-pathway and energy metabolism could bring good results in terms of metabolic balance and prevention of drug resistance

doi:10.1007/s11095-007-9348-7 80