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Clinical trials demonstrate these medications decrease triglycerides by 15-25%, lower LDL cholesterol by 3-7%, and modestly increase HDL cholesterol

Although the FAERS database aids in detecting rare adverse events via spontaneous reporting, its propensity to overestimate unexpected adverse events linked to new therapies makes it inappropriate for comparative analysis of adverse event frequencies among pharmaceuticals

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Supplementary Table 1), and in people of European ancestry 11 (BMI % = 12.1% in Europeans versus 10.6% in non-Europeans