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In subjects with renal impairment including kidney failure, no clinically relevant change in semaglutide pharmacokinetics (PK) was observed [see Clinical Pharmacology (12.3)]

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This process avoids adding external molecules since interferon gamma (IFN-) and tumor necrosis factor-alpha (TNF-), two cytokines associated to the SASP, act as natural adjuvant by promoting an immunoreaction