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For men who have both obesity and documented hypogonadism, this combination addresses the problem from two directions simultaneously: tirzepatide targets the metabolic and adipose-driven suppression of testosterone, while TRT provides direct hormone restoration

This stimulatory effect occurs through multiple mechanisms, including increased COL1A1 and COL1A2 gene transcription, enhanced procollagen mRNA stability, and improved post-translational processing of procollagen molecules

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