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I've also read about once the process is overridden by saturation of B12 there's no going back to the natural process that was failing anyway

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These results suggest that the copper metabolism in the slcr-46.1 mutant causes neither lethal nor severe phenotypic abnormalities under normal cultivation conditions and that defects arise only upon cold exposure

Some vendor and storage guides mention wider windows such as 3-6 weeks, but that does not mean every vial should be pushed to the longest possible date