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Doherty, University College Dublin, Ireland Reviewed by Jonathan Soldera, University of Caxias do Sul, Brazil Agnese Favale, University of Cagliari, Italy Updates Copyright 2026 Lee, Bajgain and Lightner

Conclusion: This study revealed a critical role of CRL3 in hepatic metabolic regulation and identified NRF2-mediated NADH-reductive stress as a previously unrecognized downstream effector modulating the development of hepatic steatosis

In addition, no acne side effects were seen with the short-acting GLP-1 receptor agonists, including liraglutide, lixisenatide, and semaglutide (Rybelsus)

2000 7.Dikbas O, Tosun M, Bes C, Tonuk SB, Aksehirli OY, Soy M

Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes