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As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish

At 72 weeks, tirzepatide produced 20.2% weight reduction versus 13.7% with semaglutide a 47% greater relative weight loss

Factor #1: Weight loss restores ovulation (sometimes very quickly) The mechanism works like this: Excess body fat produces estrogen and disrupts normal ovulation, while fat cells also produce inflammatory compounds that interfere with reproductive hormones

These problems range from severe nausea and vomiting to more serious conditions like gastroparesis

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