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First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Smith et al., 2021)

Effect of Centella asiatica extract on nociception, experimental diabetes and hyperlipidemia in mice and rats

Figure 7 In the MT treatment, the DAMs in YE988 vs

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies