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10.1021/acsnano.2c03222 85 ZhongX

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Gastric Emptying Modulation Dual Pathway Effect Both components contribute to delayed gastric emptying through complementary mechanisms[5]: GLP3 delays gastric emptying primarily through GLP-1R and glucagon receptor pathways Cagrilintide slows gastric transit through amylin and calcitonin receptor activation Combined effects produce more sustained gastric delay than single agents Prolonged nutrient exposure in the small intestine enhances incretin release This dual-pathway gastric slowing mechanism may explain enhanced satiety and reduced caloric intake observed in combination studies

Highlights GDC temporarily decreases TEER in Caco-2/HT29-MTX monolayers, without cytotoxicity GDC decreases OCLN fluorescence intensity and increases lactulose paracellular transport GDC increases acidic mucins production and decreases intracellular cAMP GDC treated monolayers are biocompatible with Infant Formula digesta 1 Introduction The infant gut barrier has a higher paracellular permeability during early development ( There are ethical and logistical challenges of conducting clinical trials in early infancy to understand the gut barrier

Appl Microbiol Biotechnol 77:12331240