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Loperamide may be used occasionally for symptomatic relief, but patients should consult a pharmacist or clinician if they need to use it repeatedly or for more than 48 hours

The New England Journal of Medicine , 375(19), 1834-1844

The second study with 426 patients randomly assigned to TAK-875, placebo, or glimepiride treatment groups showed significant reductions in HbA1c levels from baseline in the TAK-875 (6.25 to 50 mg) and glimepiride (4 mg) treatment groups compared with the placebo group at week 12 [60]

620 Astrocytic production of glutamine and associated glutamate-glutamine shuttle operation are reduced in AD, affecting synaptic transmission as well as detoxification of ammonium

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