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When methionine availability increases, SAM levels rise and promotes the dissociation of the SAMTOR-GATOR1 complex

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This selectivity means you get the growth hormone benefits without the stress hormone spikes, appetite increases, or water retention that other peptides can cause

Panel B of Figure 5 shows that the fluctuations in methionine input cause very large fluctuations in SAM but only modest fluctuations in intracellular methionine concentration, as suggested by the early methionine loading experiments of Finkelstein and co-workers [53, 54]